Human DHLAG (CD74) activation kit by CRISPRa

CAT#: GA100693

CD74 CRISPRa kit - CRISPR gene activation of human CD74 molecule

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: CD74
• Locus ID: 972
• Kit Components:

  GA100693G1, DHLAG gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100693G2, DHLAG gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100693G3, DHLAG gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001025158, NM_001025159, NM_004355, NR_157074, NM_001364083, NM_001364084
• Synonyms: DHLAG; HLADG; Ia-GAMMA; II
• Summary: 'The protein encoded by this gene associates with class II major histocompatibility complex (MHC) and is an important chaperone that regulates antigen presentation for immune response. It also serves as cell surface receptor for the cytokine macrophage migration inhibitory factor (MIF) which, when bound to the encoded protein, initiates survival pathways and cell proliferation. This protein also interacts with amyloid precursor protein (APP) and suppresses the production of amyloid beta (Abeta). Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]'