Human CDK1 activation kit by CRISPRa

CAT#: GA100700

CDK1 CRISPRa kit - CRISPR gene activation of human cyclin dependent kinase 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: CDK1
• Locus ID: 983
• Kit Components:

  GA100700G1, CDK1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100700G2, CDK1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100700G3, CDK1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001130829, NM_001170406, NM_001170407, NM_001786, NM_033379, NM_001320918
• Synonyms: CDC28A; CDK1; DKFZp686L20222; MGC111195
• Summary: 'The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is a catalytic subunit of the highly conserved protein kinase complex known as M-phase promoting factor (MPF), which is essential for G1/S and G2/M phase transitions of eukaryotic cell cycle. Mitotic cyclins stably associate with this protein and function as regulatory subunits. The kinase activity of this protein is controlled by cyclin accumulation and destruction through the cell cycle. The phosphorylation and dephosphorylation of this protein also play important regulatory roles in cell cycle control. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]'