Human SEPTIN7 activation kit by CRISPRa

CAT#: GA100704

SEPTIN7 CRISPRa kit - CRISPR gene activation of human septin 7

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: SEPTIN7
• Locus ID: 989
• Kit Components:

  GA100704G1, SEPTIN7 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100704G2, SEPTIN7 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100704G3, SEPTIN7 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001011553, NM_001242956, NM_001788, NM_001363715
• Synonyms: CDC3; CDC10; NBLA02942; SEPT7A
• Summary: 'This gene encodes a protein that is highly similar to the CDC10 protein of Saccharomyces cerevisiae. The protein also shares similarity with Diff 6 of Drosophila and with H5 of mouse. Each of these similar proteins, including the yeast CDC10, contains a GTP-binding motif. The yeast CDC10 protein is a structural component of the 10 nm filament which lies inside the cytoplasmic membrane and is essential for cytokinesis. This human protein functions in gliomagenesis and in the suppression of glioma cell growth, and it is required for the association of centromere-associated protein E with the kinetochore. Alternative splicing results in multiple transcript variants. Several related pseudogenes have been identified on chromosomes 5, 7, 9, 10, 11, 14, 17 and 19. [provided by RefSeq, Jul 2011]'