Human CDC6 activation kit by CRISPRa

CAT#: GA100705

CDC6 CRISPRa kit - CRISPR gene activation of human cell division cycle 6

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: CDC6
• Locus ID: 990
• Kit Components:

  GA100705G1, CDC6 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100705G2, CDC6 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100705G3, CDC6 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001254
• Synonyms: CDC18L; HsCDC6; HsCDC18
• Summary: 'The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc6, a protein essential for the initiation of DNA replication. This protein functions as a regulator at the early steps of DNA replication. It localizes in cell nucleus during cell cyle G1, but translocates to the cytoplasm at the start of S phase. The subcellular translocation of this protein during cell cyle is regulated through its phosphorylation by Cdks. Transcription of this protein was reported to be regulated in response to mitogenic signals through transcriptional control mechanism involving E2F proteins. [provided by RefSeq, Jul 2008]'