Human CDC25A activation kit by CRISPRa

CAT#: GA100707

CDC25A CRISPRa kit - CRISPR gene activation of human cell division cycle 25A

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: CDC25A
• Locus ID: 993
• Kit Components:

  GA100707G1, CDC25A gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100707G2, CDC25A gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100707G3, CDC25A gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001789, NM_201567
• Synonyms: CDC25A2
• Summary: CDC25A is a member of the CDC25 family of phosphatases. CDC25A is required for progression from G1 to the S phase of the cell cycle. It activates the cyclin-dependent kinase CDC2 by removing two phosphate groups. CDC25A is specifically degraded in response to DNA damage, which prevents cells with chromosomal abnormalities from progressing through cell division. CDC25A is an oncogene, although its exact role in oncogenesis has not been demonstrated. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]