Human R Cadherin (CDH4) activation kit by CRISPRa

CAT#: GA100716

CDH4 CRISPRa kit - CRISPR gene activation of human cadherin 4

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: CDH4
• Locus ID: 1002
• Kit Components:

  GA100716G1, R Cadherin gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100716G2, R Cadherin gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100716G3, R Cadherin gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001252338, NM_001252339, NM_001794
• Synonyms: CAD4; R-CAD; RCAD
• Summary: 'This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Based on studies in chicken and mouse, this cadherin is thought to play an important role during brain segmentation and neuronal outgrowth. In addition, a role in kidney and muscle development is indicated. Of particular interest are studies showing stable cis-heterodimers of cadherins 2 and 4 in cotransfected cell lines. Previously thought to interact in an exclusively homophilic manner, this is the first evidence of cadherin heterodimerization. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]'