Human CDHH (CDH13) activation kit by CRISPRa

CAT#: GA100725

CDH13 CRISPRa kit - CRISPR gene activation of human cadherin 13

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: CDH13
• Locus ID: 1012
• Kit Components:

  GA100725G1, CDHH gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100725G2, CDHH gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100725G3, CDHH gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001220488, NM_001220489, NM_001220490, NM_001220491, NM_001220492, NM_001257
• Synonyms: CDHH; P105
• Summary: 'This gene encodes a member of the cadherin superfamily. The encoded protein is localized to the surface of the cell membrane and is anchored by a GPI moiety, rather than by a transmembrane domain. The protein lacks the cytoplasmic domain characteristic of other cadherins, and so is not thought to be a cell-cell adhesion glycoprotein. This protein acts as a negative regulator of axon growth during neural differentiation. It also protects vascular endothelial cells from apoptosis due to oxidative stress, and is associated with resistance to atherosclerosis. The gene is hypermethylated in many types of cancer. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2011]'