Human p18 INK4c (CDKN2C) activation kit by CRISPRa

CAT#: GA100743

CDKN2C CRISPRa kit - CRISPR gene activation of human cyclin dependent kinase inhibitor 2C

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: CDKN2C
• Locus ID: 1031
• Kit Components:

  GA100743G1, p18 INK4c gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100743G2, p18 INK4c gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100743G3, p18 INK4c gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001262, NM_078626
• Synonyms: INK4C; p18; p18-INK4C
• Summary: 'The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to interact with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. Ectopic expression of this gene was shown to suppress the growth of human cells in a manner that appears to correlate with the presence of a wild-type RB1 function. Studies in the knockout mice suggested the roles of this gene in regulating spermatogenesis, as well as in suppressing tumorigenesis. Two alternatively spliced transcript variants of this gene, which encode an identical protein, have been reported. [provided by RefSeq, Jul 2008]'