Human CEBP Alpha (CEBPA) activation kit by CRISPRa

CAT#: GA100757

CEBPA CRISPRa kit - CRISPR gene activation of human CCAAT enhancer binding protein alpha

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: CEBPA
• Locus ID: 1050
• Kit Components:

  GA100757G1, CEBP Alpha gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100757G2, CEBP Alpha gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100757G3, CEBP Alpha gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001285829, NM_001287424, NM_001287435, NM_004364, NM_001287424.2
• Synonyms: C/EBP-alpha; CEBP
• Summary: This intronless gene encodes a transcription factor that contains a basic leucine zipper (bZIP) domain and recognizes the CCAAT motif in the promoters of target genes. The encoded protein functions in homodimers and also heterodimers with CCAAT/enhancer-binding proteins beta and gamma. Activity of this protein can modulate the expression of genes involved in cell cycle regulation as well as in body weight homeostasis. Mutation of this gene is associated with acute myeloid leukemia. The use of alternative in-frame non-AUG (GUG) and AUG start codons results in protein isoforms with different lengths. Differential translation initiation is mediated by an out-of-frame, upstream open reading frame which is located between the GUG and the first AUG start codons. [provided by RefSeq, Dec 2013]