Human Chimaerin 2 (CHN2) activation kit by CRISPRa

CAT#: GA100804

CHN2 CRISPRa kit - CRISPR gene activation of human chimerin 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: CHN2
• Locus ID: 1124
• Kit Components:

  GA100804G1, Chimaerin 2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100804G2, Chimaerin 2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100804G3, Chimaerin 2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001039936, NM_001293069, NM_001293070, NM_001293071, NM_001293072, NM_001293073, NM_001293075, NM_001293076, NM_001293077, NM_001293078, NM_001293079, NM_001293080, NM_001293081, NM_004067, NR_120524, NR_120525
• Synonyms: ARHGAP3; BCH; CHN2-3; RHOGAP3
• Summary: 'This gene encodes a guanosine triphosphate (GTP)-metabolizing protein that contains a phorbol-ester/diacylglycerol (DAG)-type zinc finger, a Rho-GAP domain, and an SH2 domain. The encoded protein translocates from the cytosol to the Golgi apparatus membrane upon binding by diacylglycerol (DAG). Activity of this protein is important in cell proliferation and migration, and expression changes in this gene have been detected in cancers. A mutation in this gene has also been associated with schizophrenia in men. Alternative transcript splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, May 2014]'