Human CHRM1 activation kit by CRISPRa

CAT#: GA100805

CHRM1 CRISPRa kit - CRISPR gene activation of human cholinergic receptor muscarinic 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: CHRM1
• Locus ID: 1128
• Kit Components:

  GA100805G1, CHRM1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100805G2, CHRM1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100805G3, CHRM1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000738
• Synonyms: HM1; M1; M1R
• Summary: 'The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 1 is involved in mediation of vagally-induced bronchoconstriction and in the acid secretion of the gastrointestinal tract. The gene encoding this receptor is localized to 11q13. [provided by RefSeq, Jul 2008]'