Human CHRM2 activation kit by CRISPRa

CAT#: GA100806

CHRM2 CRISPRa kit - CRISPR gene activation of human cholinergic receptor muscarinic 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: CHRM2
• Locus ID: 1129
• Kit Components:

  GA100806G1, CHRM2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100806G2, CHRM2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100806G3, CHRM2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000739, NM_001006626, NM_001006627, NM_001006628, NM_001006629, NM_001006630, NM_001006631, NM_001006632, NM_001006633
• Synonyms: HM2
• Summary: 'The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine to these receptors and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 2 is involved in mediation of bradycardia and a decrease in cardiac contractility. Multiple alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jul 2008]'