Human CLCN4 activation kit by CRISPRa

CAT#: GA100845

CLCN4 CRISPRa kit - CRISPR gene activation of human chloride voltage-gated channel 4

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: CLCN4
• Locus ID: 1183
• Kit Components:

  GA100845G1, CLCN4 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100845G2, CLCN4 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100845G3, CLCN4 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001256944, NM_001830
• Synonyms: ClC-4; ClC-4A; CLC4
• Summary: 'The CLCN family of voltage-dependent chloride channel genes comprises nine members (CLCN1-7, Ka and Kb) which demonstrate quite diverse functional characteristics while sharing significant sequence homology. Chloride channel 4 has an evolutionary conserved CpG island and is conserved in both mouse and hamster. This gene is mapped in close proximity to APXL (Apical protein Xenopus laevis-like) and OA1 (Ocular albinism type I), which are both located on the human X chromosome at band p22.3. The physiological role of chloride channel 4 remains unknown but may contribute to the pathogenesis of neuronal disorders. Alternate splicing results in two transcript variants that encode different proteins. [provided by RefSeq, Mar 2012]'