Human TPP1 activation kit by CRISPRa

CAT#: GA100857

TPP1 CRISPRa kit - CRISPR gene activation of human tripeptidyl peptidase 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: TPP1
• Locus ID: 1200
• Kit Components:

  GA100857G1, TPP1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100857G2, TPP1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100857G3, TPP1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000391
• Synonyms: CLN2; GIG1; LPIC; SCAR7; TPP-1
• Summary: 'This gene encodes a member of the sedolisin family of serine proteases. The protease functions in the lysosome to cleave N-terminal tripeptides from substrates, and has weaker endopeptidase activity. It is synthesized as a catalytically-inactive enzyme which is activated and auto-proteolyzed upon acidification. Mutations in this gene result in late-infantile neuronal ceroid lipofuscinosis, which is associated with the failure to degrade specific neuropeptides and a subunit of ATP synthase in the lysosome. [provided by RefSeq, Jul 2008]'