Human CMA1 activation kit by CRISPRa

CAT#: GA100866

CMA1 CRISPRa kit - CRISPR gene activation of human chymase 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: CMA1
• Locus ID: 1215
• Kit Components:

  GA100866G1, CMA1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100866G2, CMA1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100866G3, CMA1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001308083, NM_001836
• Synonyms: chymase; CYH; MCT1
• Summary: 'This gene encodes a chymotryptic serine proteinase that belongs to the peptidase family S1. It is expressed in mast cells and is thought to function in the degradation of the extracellular matrix, the regulation of submucosal gland secretion, and the generation of vasoactive peptides. In the heart and blood vessels, this protein, rather than angiotensin converting enzyme, is largely responsible for converting angiotensin I to the vasoactive peptide angiotensin II. Alternative splicing results in multiple variants. [provided by RefSeq, Apr 2015]'