Human CCR3 activation kit by CRISPRa

CAT#: GA100868

CCR3 CRISPRa kit - CRISPR gene activation of human C-C motif chemokine receptor 3

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: CCR3
• Locus ID: 1232
• Kit Components:

  GA100868G1, CCR3 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100868G2, CCR3 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100868G3, CCR3 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001164680, NM_001837, NM_178328, NM_178329
• Synonyms: CC-CKR-3; CD193; CKR3; CMKBR3
• Summary: 'The protein encoded by this gene is a receptor for C-C type chemokines. It belongs to family 1 of the G protein-coupled receptors. This receptor binds and responds to a variety of chemokines, including eotaxin (CCL11), eotaxin-3 (CCL26), MCP-3 (CCL7), MCP-4 (CCL13), and RANTES (CCL5). It is highly expressed in eosinophils and basophils, and is also detected in TH1 and TH2 cells, as well as in airway epithelial cells. This receptor may contribute to the accumulation and activation of eosinophils and other inflammatory cells in the allergic airway. It is also known to be an entry co-receptor for HIV-1. This gene and seven other chemokine receptor genes form a chemokine receptor gene cluster on the chromosomal region 3p21. Alternatively spliced transcript variants have been described. [provided by RefSeq, Sep 2009]'