Human Cannabinoid Receptor I (CNR1) activation kit by CRISPRa

CAT#: GA100888

CNR1 CRISPRa kit - CRISPR gene activation of human cannabinoid receptor 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: CNR1
• Locus ID: 1268
• Kit Components:

  GA100888G1, Cannabinoid Receptor I gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100888G2, Cannabinoid Receptor I gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100888G3, Cannabinoid Receptor I gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001160226, NM_001160258, NM_001160259, NM_001160260, NM_001840, NM_016083, NM_033181, NM_001365872, NM_001370545, NM_001365869, NM_001365870, NM_001365874, NM_001370546, NM_001370547
• Synonyms: CANN6; CB-R; CB1; CB1A; CB1K5; CB1R; CNR
• Summary: 'This gene encodes one of two cannabinoid receptors. The cannabinoids, principally delta-9-tetrahydrocannabinol and synthetic analogs, are psychoactive ingredients of marijuana. The cannabinoid receptors are members of the guanine-nucleotide-binding protein (G-protein) coupled receptor family, which inhibit adenylate cyclase activity in a dose-dependent, stereoselective and pertussis toxin-sensitive manner. The two receptors have been found to be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana. Multiple transcript variants encoding two different protein isoforms have been described for this gene. [provided by RefSeq, May 2009]'