Human Collagen III (COL3A1) activation kit by CRISPRa

CAT#: GA100896

COL3A1 CRISPRa kit - CRISPR gene activation of human collagen type III alpha 1 chain

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: COL3A1
• Locus ID: 1281
• Kit Components:

  GA100896G1, Collagen III gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100896G2, Collagen III gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100896G3, Collagen III gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000090
• Synonyms: EDS4A
• Summary: 'This gene encodes the pro-alpha1 chains of type III collagen, a fibrillar collagen that is found in extensible connective tissues such as skin, lung, uterus, intestine and the vascular system, frequently in association with type I collagen. Mutations in this gene are associated with Ehlers-Danlos syndrome types IV, and with aortic and arterial aneurysms. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene. [provided by R. Dalgleish, Feb 2008]'