Human Collagen V (COL5A1) activation kit by CRISPRa

CAT#: GA100903

COL5A1 CRISPRa kit - CRISPR gene activation of human collagen type V alpha 1 chain

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: COL5A1
• Locus ID: 1289
• Kit Components:

  GA100903G1, Collagen V gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100903G2, Collagen V gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100903G3, Collagen V gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000093, NM_001278074
• Synonyms: alpha 1 type V collagen; collagen, type V, alpha 1; OTTHUMP00000022513; OTTHUMP00000064637
• Summary: 'This gene encodes an alpha chain for one of the low abundance fibrillar collagens. Fibrillar collagen molecules are trimers that can be composed of one or more types of alpha chains. Type V collagen is found in tissues containing type I collagen and appears to regulate the assembly of heterotypic fibers composed of both type I and type V collagen. This gene product is closely related to type XI collagen and it is possible that the collagen chains of types V and XI constitute a single collagen type with tissue-specific chain combinations. The encoded procollagen protein occurs commonly as the heterotrimer pro-alpha1(V)-pro-alpha1(V)-pro-alpha2(V). Mutations in this gene are associated with Ehlers-Danlos syndrome, types I and II. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2013]'