Human Collagen VII (COL7A1) activation kit by CRISPRa

CAT#: GA100908

COL7A1 CRISPRa kit - CRISPR gene activation of human collagen type VII alpha 1 chain

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: COL7A1
• Locus ID: 1294
• Kit Components:

  GA100908G1, Collagen VII gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100908G2, Collagen VII gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100908G3, Collagen VII gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000094
• Synonyms: EBD1; EBDCT; EBR1; NDNC8
• Summary: 'This gene encodes the alpha chain of type VII collagen. The type VII collagen fibril, composed of three identical alpha collagen chains, is restricted to the basement zone beneath stratified squamous epithelia. It functions as an anchoring fibril between the external epithelia and the underlying stroma. Mutations in this gene are associated with all forms of dystrophic epidermolysis bullosa. In the absence of mutations, however, an acquired form of this disease can result from an autoimmune response made to type VII collagen. [provided by RefSeq, Jul 2008]'