Human COL11A1 activation kit by CRISPRa

CAT#: GA100915

COL11A1 CRISPRa kit - CRISPR gene activation of human collagen type XI alpha 1 chain

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: COL11A1
• Locus ID: 1301
• Kit Components:

  GA100915G1, COL11A1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100915G2, COL11A1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100915G3, COL11A1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001168249, NM_001190709, NM_001854, NM_080629, NM_080630, NR_134980
• Synonyms: CO11A1; COLL6; STL2
• Summary: 'This gene encodes one of the two alpha chains of type XI collagen, a minor fibrillar collagen. Type XI collagen is a heterotrimer but the third alpha chain is a post-translationally modified alpha 1 type II chain. Mutations in this gene are associated with type II Stickler syndrome and with Marshall syndrome. A single-nucleotide polymorphism in this gene is also associated with susceptibility to lumbar disc herniation. Multiple transcript variants have been identified for this gene. [provided by RefSeq, Nov 2009]'