Human COMP activation kit by CRISPRa

CAT#: GA100923

COMP CRISPRa kit - CRISPR gene activation of human cartilage oligomeric matrix protein

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: COMP
• Locus ID: 1311
• Kit Components:

  GA100923G1, COMP gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100923G2, COMP gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100923G3, COMP gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000095
• Synonyms: EDM1; EPD1; MED; PSACH; THBS5
• Summary: 'The protein encoded by this gene is a noncollagenous extracellular matrix (ECM) protein. It consists of five identical glycoprotein subunits, each with EGF-like and calcium-binding (thrombospondin-like) domains. Oligomerization results from formation of a five-stranded coiled coil and disulfides. Binding to other ECM proteins such as collagen appears to depend on divalent cations. Contraction or expansion of a 5 aa aspartate repeat and other mutations can cause pseudochondroplasia (PSACH) and multiple epiphyseal dysplasia (MED). [provided by RefSeq, Jul 2016]'