Human COX4 (COX4I1) activation kit by CRISPRa

CAT#: GA100932

COX4I1 CRISPRa kit - CRISPR gene activation of human cytochrome c oxidase subunit 4I1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: COX4I1
• Locus ID: 1327
• Kit Components:

  GA100932G1, COX4 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100932G2, COX4 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100932G3, COX4 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001318786, NM_001318788, NM_001318794, NM_001318797, NM_001318802, NM_001861
• Synonyms: COX4; COX4-1; COXIV; COX IV-1; COXIV-1
• Summary: 'Cytochrome c oxidase (COX) is the terminal enzyme of the mitochondrial respiratory chain. It is a multi-subunit enzyme complex that couples the transfer of electrons from cytochrome c to molecular oxygen and contributes to a proton electrochemical gradient across the inner mitochondrial membrane. The complex consists of 13 mitochondrial- and nuclear-encoded subunits. The mitochondrially-encoded subunits perform the electron transfer and proton pumping activities. The functions of the nuclear-encoded subunits are unknown but they may play a role in the regulation and assembly of the complex. This gene encodes the nuclear-encoded subunit IV isoform 1 of the human mitochondrial respiratory chain enzyme. It is located at the 3' of the NOC4 (neighbor of COX4) gene in a head-to-head orientation, and shares a promoter with it. Pseudogenes related to this gene are located on chromosomes 13 and 14. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]'