Human COX7A2 activation kit by CRISPRa

CAT#: GA100939

COX7A2 CRISPRa kit - CRISPR gene activation of human cytochrome c oxidase subunit 7A2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: COX7A2
• Locus ID: 1347
• Kit Components:

  GA100939G1, COX7A2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100939G2, COX7A2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100939G3, COX7A2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001865, NR_029466, NM_001366292, NM_001366293, NR_158784, NR_158783
• Synonyms: COX7AL; COX7AL1; COXVIIa-L; COXVIIAL; VIIAL
• Summary: 'Cytochrome c oxidase, the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of three catalytic subunits encoded by mitochondrial genes, and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, while the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes polypeptide 2 (liver isoform) of subunit VIIa, with this polypeptide being present in both muscle and non-muscle tissues. In addition to polypeptide 2, subunit VIIa includes polypeptide 1 (muscle isoform), which is present only in muscle tissues, and a related protein, which is present in all tissues. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 4 and 14. [provided by RefSeq, Oct 2009]'