Human COX7C activation kit by CRISPRa

CAT#: GA100941

COX7C CRISPRa kit - CRISPR gene activation of human cytochrome c oxidase subunit 7C

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: COX7C
• Locus ID: 1350
• Kit Components:

  GA100941G1, COX7C gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100941G2, COX7C gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100941G3, COX7C gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001867
• Synonyms: cytochrome-c oxidase chain VIIc; cytochrome c oxidase subunit VIIc
• Summary: 'Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes subunit VIIc, which shares 87% and 85% amino acid sequence identity with mouse and bovine COX VIIc, respectively, and is found in all tissues. A pseudogene COX7CP1 has been found on chromosome 13. [provided by RefSeq, Jul 2008]'