Human CPS1 activation kit by CRISPRa

CAT#: GA100961

CPS1 CRISPRa kit - CRISPR gene activation of human carbamoyl-phosphate synthase 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: CPS1
• Locus ID: 1373
• Kit Components:

  GA100961G1, CPS1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100961G2, CPS1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100961G3, CPS1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001122633, NM_001122634, NM_001875, NR_163592, NM_001369256, NM_001369257, NR_161225
• Synonyms: CPSASE1; PHN
• Summary: 'The mitochondrial enzyme encoded by this gene catalyzes synthesis of carbamoyl phosphate from ammonia and bicarbonate. This reaction is the first committed step of the urea cycle, which is important in the removal of excess urea from cells. The encoded protein may also represent a core mitochondrial nucleoid protein. Three transcript variants encoding different isoforms have been found for this gene. The shortest isoform may not be localized to the mitochondrion. Mutations in this gene have been associated with carbamoyl phosphate synthetase deficiency, susceptibility to persistent pulmonary hypertension, and susceptibility to venoocclusive disease after bone marrow transplantation.[provided by RefSeq, May 2010]'