CPS1 Rabbit Monoclonal Antibody [Clone ID: EPR7493]

CAT#: TA310349

Rabbit Monoclonal antibody against CPS1

Product Images

Western blot - Anti-CPS1 antibody [EPR7493]; All lanes : Anti-CPS1 antibody [EPR7493] at 1/1000 dilution.Lane 1 : Fetal liver cell lysate.Lane 2 : Mouse liver cell lysate.Lane 3 : Rat liver cell lysate.Lane 4 : HeLa cell lysate.Predicted band size : 165 kDa.Observed band size : 150 kDa.

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  Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CPS1 antibody [EPR7493]; TA310349, at 1/100 dilution staining CPS1 in formalin fixed paraffin embedded Human liver tissue by immunohistochemistry

Specifications

Product Data

• Clone Name: EPR7493
• Applications: IHC, WB
• Recommended Dilution: WB: 1:1000 - 1:10000; IP: 1:10 - 1:100; IHC-P: 1:100 - 1:250; ICC/IF: 1:50 - 1:100
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Monoclonal
• Immunogen: A synthetic peptide corresponding to residues in human CPS1 was used as an immunogen.
• Formulation: pH: 7.20
  Preservative: 0.01% Sodium azide
  Constituents: 49% PBS, 50% Glycerol, 0.05% BSA
• Purification: Tissue culture supernatant
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 165 kDa
• Gene Name: carbamoyl-phosphate synthase 1
• Database Link:
  NP_001116105
  Entrez Gene 227231 MouseEntrez Gene 497840 RatEntrez Gene 1373 Human
  UniProt ID P31327
• Background: The mitochondrial enzyme catalyzes synthesis of carbamoyl phosphate from ammonia and bicarbonate. This reaction is the first committed step of the urea cycle, which is important in the removal of excess urea from cells. CPS1 also represents a core mitochondrial nucleoid protein. The shortest isoform may not be localized to the mitochondrion. Mutations in CPS1 have been associated with carbamoyl phosphate synthetase deficiency, susceptibility to persistent pulmonary hypertension, and susceptibility to venoocclusive disease after bone marrow transplantation (1).
• Synonyms: CPSASE1; PHN
• Note: Is unsuitable for Flow Cyt.

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Alanine, aspartate and glutamate metabolism, Arginine and proline metabolism, Metabolic pathways, Nitrogen metabolism