Human CPT1A activation kit by CRISPRa

CAT#: GA100962

CPT1A CRISPRa kit - CRISPR gene activation of human carnitine palmitoyltransferase 1A

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: CPT1A
• Locus ID: 1374
• Kit Components:

  GA100962G1, CPT1A gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100962G2, CPT1A gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100962G3, CPT1A gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001031847, NM_001876
• Synonyms: CPT1; CPT1-L; L-CPT1
• Summary: 'The mitochondrial oxidation of long-chain fatty acids is initiated by the sequential action of carnitine palmitoyltransferase I (which is located in the outer membrane and is detergent-labile) and carnitine palmitoyltransferase II (which is located in the inner membrane and is detergent-stable), together with a carnitine-acylcarnitine translocase. CPT I is the key enzyme in the carnitine-dependent transport across the mitochondrial inner membrane and its deficiency results in a decreased rate of fatty acid beta-oxidation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]'