Human ATF2 activation kit by CRISPRa

CAT#: GA100972

ATF2 CRISPRa kit - CRISPR gene activation of human activating transcription factor 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: ATF2
• Locus ID: 1386
• Kit Components:

  GA100972G1, ATF2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100972G2, ATF2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100972G3, ATF2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001256090, NM_001256091, NM_001256092, NM_001256093, NM_001256094, NM_001880, NR_045768, NR_045769, NR_045770, NR_045771, NR_045772, NR_045773, NR_045774
• Synonyms: CRE-BP1; CREB-2; CREB2; HB16; TREB7
• Summary: 'This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions This protein binds to the cAMP-responsive element (CRE), an octameric palindrome. It forms a homodimer or a heterodimer with c-Jun and stimulates CRE-dependent transcription. This protein is also a histone acetyltransferase (HAT) that specifically acetylates histones H2B and H4 in vitro; thus it may represent a class of sequence-specific factors that activate transcription by direct effects on chromatin components. The encoded protein may also be involved in cell's DNA damage response independent of its role in transcriptional regulation. Several alternatively spliced transcript variants have been found for this gene [provided by RefSeq, Jan 2014]'