Human CREM activation kit by CRISPRa

CAT#: GA100976

CREM CRISPRa kit - CRISPR gene activation of human cAMP responsive element modulator

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: CREM
• Locus ID: 1390
• Kit Components:

  GA100976G1, CREM gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100976G2, CREM gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100976G3, CREM gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001267562, NM_001267563, NM_001267564, NM_001267565, NM_001267566, NM_001267567, NM_001267568, NM_001267569, NM_001267570, NM_001881, NM_181571, NM_182717, NM_182718, NM_182719, NM_182720, NM_182721, NM_182722, NM_182723, NM_182724, NM_182725, NM_182769, NM_182770, NM_182771, NM_182772, NM_182850, NM_182853, NM_183011, NM_183012, NM_183013, NM_183060, NR_051971, NR_051972, NR_051973, NR_051974, NR_051975, NM_001352445, NM_001352446, NM_001352465, NM_001352466, NM_001352467, NM_001267563.2
• Synonyms: CREM-2; hCREM-2; ICER
• Summary: 'This gene encodes a bZIP transcription factor that binds to the cAMP responsive element found in many viral and cellular promoters. It is an important component of cAMP-mediated signal transduction during the spermatogenetic cycle, as well as other complex processes. Alternative promoter and translation initiation site usage allows this gene to exert spatial and temporal specificity to cAMP responsiveness. Multiple alternatively spliced transcript variants encoding several different isoforms have been found for this gene, with some of them functioning as activators and some as repressors of transcription. [provided by RefSeq, Jul 2008]'