Human CRHBP activation kit by CRISPRa

CAT#: GA100978

CRHBP CRISPRa kit - CRISPR gene activation of human corticotropin releasing hormone binding protein

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: CRHBP
• Locus ID: 1393
• Kit Components:

  GA100978G1, CRHBP gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA100978G2, CRHBP gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA100978G3, CRHBP gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001882
• Synonyms: CRF-BP; CRFBP
• Summary: 'Corticotropin-releasing hormone is a potent stimulator of synthesis and secretion of preopiomelanocortin-derived peptides. Although CRH concentrations in the human peripheral circulation are normally low, they increase throughout pregnancy and fall rapidly after parturition. Maternal plasma CRH probably originates from the placenta. Human plasma contains a CRH-binding protein which inactivates CRH and which may prevent inappropriate pituitary-adrenal stimulation in pregnancy. [provided by RefSeq, Jul 2008]'