Human mu Crystallin (CRYM) activation kit by CRISPRa

CAT#: GA101004

CRYM CRISPRa kit - CRISPR gene activation of human crystallin mu

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: CRYM
• Locus ID: 1428
• Kit Components:

  GA101004G1, mu Crystallin gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101004G2, mu Crystallin gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101004G3, mu Crystallin gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001014444, NM_001888
• Synonyms: DFNA40; THBP
• Summary: 'Crystallins are separated into two classes: taxon-specific and ubiquitous. The former class is also called phylogenetically-restricted crystallins. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. This gene encodes a taxon-specific crystallin protein that binds NADPH and has sequence similarity to bacterial ornithine cyclodeaminases. The encoded protein does not perform a structural role in lens tissue, and instead it binds thyroid hormone for possible regulatory or developmental roles. Mutations in this gene have been associated with autosomal dominant non-syndromic deafness. [provided by RefSeq, Sep 2014]'