Human Cellular Apoptosis Susceptibility (CSE1L) activation kit by CRISPRa

CAT#: GA101008

CSE1L CRISPRa kit - CRISPR gene activation of human chromosome segregation 1 like

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: CSE1L
• Locus ID: 1434
• Kit Components:

  GA101008G1, Cellular Apoptosis Susceptibility gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101008G2, Cellular Apoptosis Susceptibility gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101008G3, Cellular Apoptosis Susceptibility gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001256135, NM_001316, NM_177436, NR_045796, NM_001362762
• Synonyms: CAS; CSE1; XPO2
• Summary: 'Proteins that carry a nuclear localization signal (NLS) are transported into the nucleus by the importin-alpha/beta heterodimer. Importin-alpha binds the NLS, while importin-beta mediates translocation through the nuclear pore complex. After translocation, RanGTP binds importin-beta and displaces importin-alpha. Importin-alpha must then be returned to the cytoplasm, leaving the NLS protein behind. The protein encoded by this gene binds strongly to NLS-free importin-alpha, and this binding is released in the cytoplasm by the combined action of RANBP1 and RANGAP1. In addition, the encoded protein may play a role both in apoptosis and in cell proliferation. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012]'