Human CTBP2 activation kit by CRISPRa

CAT#: GA101052

CTBP2 CRISPRa kit - CRISPR gene activation of human C-terminal binding protein 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: CTBP2
• Locus ID: 1488
• Kit Components:

  GA101052G1, CTBP2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101052G2, CTBP2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101052G3, CTBP2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001083914, NM_001290214, NM_001290215, NM_001321012, NM_001321013, NM_001321014, NM_001329, NM_022802, NM_001363508
• Synonyms: C-terminal binding protein 2; OTTHUMP00000020699; OTTHUMP00000020701; ribeye
• Summary: 'This gene produces alternative transcripts encoding two distinct proteins. One protein is a transcriptional repressor, while the other isoform is a major component of specialized synapses known as synaptic ribbons. Both proteins contain a NAD+ binding domain similar to NAD+-dependent 2-hydroxyacid dehydrogenases. A portion of the 3' untranslated region was used to map this gene to chromosome 21q21.3; however, it was noted that similar loci elsewhere in the genome are likely. Blast analysis shows that this gene is present on chromosome 10. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Feb 2014]'