Human Cathepsin L (CTSL) activation kit by CRISPRa

CAT#: GA101072

CTSL CRISPRa kit - CRISPR gene activation of human cathepsin L

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: CTSL
• Locus ID: 1514
• Kit Components:

  GA101072G1, Cathepsin L gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101072G2, Cathepsin L gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101072G3, Cathepsin L gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001257971, NM_001257972, NM_001257973, NM_001912, NM_145918
• Synonyms: CATL; CTSL1; MEP
• Summary: 'The protein encoded by this gene is a lysosomal cysteine proteinase that plays a major role in intracellular protein catabolism. Its substrates include collagen and elastin, as well as alpha-1 protease inhibitor, a major controlling element of neutrophil elastase activity. The encoded protein has been implicated in several pathologic processes, including myofibril necrosis in myopathies and in myocardial ischemia, and in the renal tubular response to proteinuria. This protein, which is a member of the peptidase C1 family, is a dimer composed of disulfide-linked heavy and light chains, both produced from a single protein precursor. Additionally, this protein cleaves the S1 subunit of the SARS-CoV-2 spike protein, which is necessary for entry of the virus into the cell. [provided by RefSeq, Aug 2020]'