Human Cytochrome P450 2C9 (CYP2C9) activation kit by CRISPRa

CAT#: GA101100

CYP2C9 CRISPRa kit - CRISPR gene activation of human cytochrome P450 family 2 subfamily C member 9

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: CYP2C9
• Locus ID: 1559
• Kit Components:

  GA101100G1, Cytochrome P450 2C9 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101100G2, Cytochrome P450 2C9 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101100G3, Cytochrome P450 2C9 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000771
• Synonyms: CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9
• Summary: 'This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by rifampin. The enzyme is known to metabolize many xenobiotics, including phenytoin, tolbutamide, ibuprofen and S-warfarin. Studies identifying individuals who are poor metabolizers of phenytoin and tolbutamide suggest that this gene is polymorphic. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. [provided by RefSeq, Jul 2008]'