Human Cytochrome P450 17A1 (CYP17A1) activation kit by CRISPRa

CAT#: GA101116

CYP17A1 CRISPRa kit - CRISPR gene activation of human cytochrome P450 family 17 subfamily A member 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: CYP17A1
• Locus ID: 1586
• Kit Components:

  GA101116G1, Cytochrome P450 17A1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101116G2, Cytochrome P450 17A1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101116G3, Cytochrome P450 17A1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000102
• Synonyms: CPT7; CYP17; P450C17; S17AH
• Summary: 'This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. It has both 17alpha-hydroxylase and 17,20-lyase activities and is a key enzyme in the steroidogenic pathway that produces progestins, mineralocorticoids, glucocorticoids, androgens, and estrogens. Mutations in this gene are associated with isolated steroid-17 alpha-hydroxylase deficiency, 17-alpha-hydroxylase/17,20-lyase deficiency, pseudohermaphroditism, and adrenal hyperplasia. [provided by RefSeq, Jul 2008]'