Human CYP26A1 activation kit by CRISPRa

CAT#: GA101120

CYP26A1 CRISPRa kit - CRISPR gene activation of human cytochrome P450 family 26 subfamily A member 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: CYP26A1
• Locus ID: 1592
• Kit Components:

  GA101120G1, CYP26A1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101120G2, CYP26A1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101120G3, CYP26A1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000783, NM_057157
• Synonyms: CP26; CYP26; P450RAI; P450RAI1
• Summary: 'This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein acts on retinoids, including all-trans-retinoic acid (RA), with both 4-hydroxylation and 18-hydroxylation activities. This enzyme regulates the cellular level of retinoic acid which is involved in regulation of gene expression in both embryonic and adult tissues. Two alternatively spliced transcript variants of this gene, which encode the distinct isoforms, have been reported. [provided by RefSeq, Jul 2008]'