Human DAB2 activation kit by CRISPRa

CAT#: GA101125

DAB2 CRISPRa kit - CRISPR gene activation of human DAB adaptor protein 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: DAB2
• Locus ID: 1601
• Kit Components:

  GA101125G1, DAB2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101125G2, DAB2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101125G3, DAB2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001244871, NM_001343
• Synonyms: DOC-2; DOC2
• Summary: 'This gene encodes a mitogen-responsive phosphoprotein. It is expressed in normal ovarian epithelial cells, but is down-regulated or absent from ovarian carcinoma cell lines, suggesting its role as a tumor suppressor. This protein binds to the SH3 domains of GRB2, an adaptor protein that couples tyrosine kinase receptors to SOS (a guanine nucleotide exchange factor for Ras), via its C-terminal proline-rich sequences, and may thus modulate growth factor/Ras pathways by competing with SOS for binding to GRB2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]'