Human DCK activation kit by CRISPRa

CAT#: GA101150

DCK CRISPRa kit - CRISPR gene activation of human deoxycytidine kinase

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: DCK
• Locus ID: 1633
• Kit Components:

  GA101150G1, DCK gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101150G2, DCK gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101150G3, DCK gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000788
• Synonyms: MGC117410; MGC138632
• Summary: ' Deoxycytidine kinase (DCK) is required for the phosphorylation of several deoxyribonucleosides and their nucleoside analogs. Deficiency of DCK is associated with resistance to antiviral and anticancer chemotherapeutic agents. Conversely, increased deoxycytidine kinase activity is associated with increased activation of these compounds to cytotoxic nucleoside triphosphate derivatives. DCK is clinically important because of its relationship to drug resistance and sensitivity. [provided by RefSeq, Jul 2008]'