Human Decorin (DCN) activation kit by CRISPRa

CAT#: GA101151

DCN CRISPRa kit - CRISPR gene activation of human decorin

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: DCN
• Locus ID: 1634
• Kit Components:

  GA101151G1, Decorin gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101151G2, Decorin gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101151G3, Decorin gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001920, NM_133503, NM_133504, NM_133505, NM_133506, NM_133507
• Synonyms: CSCD; DSPG2; PG40; PGII; PGS2; SLRR1B
• Summary: 'This gene encodes a member of the small leucine-rich proteoglycan family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protein. This protein plays a role in collagen fibril assembly. Binding of this protein to multiple cell surface receptors mediates its role in tumor suppression, including a stimulatory effect on autophagy and inflammation and an inhibitory effect on angiogenesis and tumorigenesis. This gene and the related gene biglycan are thought to be the result of a gene duplication. Mutations in this gene are associated with congenital stromal corneal dystrophy in human patients. [provided by RefSeq, Nov 2015]'