Human DDB2 activation kit by CRISPRa

CAT#: GA101158

DDB2 CRISPRa kit - CRISPR gene activation of human damage specific DNA binding protein 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: DDB2
• Locus ID: 1643
• Kit Components:

  GA101158G1, DDB2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101158G2, DDB2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101158G3, DDB2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000107, NM_001300734
• Synonyms: DDBB; UV-DDB2; XPE
• Summary: 'This gene encodes a protein that is necessary for the repair of ultraviolet light-damaged DNA. This protein is the smaller subunit of a heterodimeric protein complex that participates in nucleotide excision repair, and this complex mediates the ubiquitylation of histones H3 and H4, which facilitates the cellular response to DNA damage. This subunit appears to be required for DNA binding. Mutations in this gene cause xeroderma pigmentosum complementation group E, a recessive disease that is characterized by an increased sensitivity to UV light and a high predisposition for skin cancer development, in some cases accompanied by neurological abnormalities. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]'