Human DDX5 activation kit by CRISPRa

CAT#: GA101168

DDX5 CRISPRa kit - CRISPR gene activation of human DEAD-box helicase 5

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: DDX5
• Locus ID: 1655
• Kit Components:

  GA101168G1, DDX5 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101168G2, DDX5 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101168G3, DDX5 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001320595, NM_001320596, NM_001320597, NM_004396, N67237
• Synonyms: G17P1; HLR1; HUMP68; p68
• Summary: 'This gene encodes a member of the DEAD box family of RNA helicases that are involved in a variety of cellular processes as a result of its role as an adaptor molecule, promoting interactions with a large number of other factors. This protein is involved in pathways that include the alteration of RNA structures, plays a role as a coregulator of transcription, a regulator of splicing, and in the processing of small noncoding RNAs. Members of this family contain nine conserved motifs, including the conserved Asp-Glu-Ala-Asp (DEAD) motif, important to ATP binding and hydrolysis as well as RNA binding and unwinding activities. Dysregulation of this gene may play a role in cancer development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2017]'