Human alpha 5 Defensin (DEFA5) activation kit by CRISPRa

CAT#: GA101180

DEFA5 CRISPRa kit - CRISPR gene activation of human defensin alpha 5

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: DEFA5
• Locus ID: 1670
• Kit Components:

  GA101180G1, alpha 5 Defensin gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101180G2, alpha 5 Defensin gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101180G3, alpha 5 Defensin gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_021010
• Synonyms: DEF5; HD-5
• Summary: 'Defensins are a family of antimicrobial and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. Several of the alpha defensin genes appear to be clustered on chromosome 8. The protein encoded by this gene, defensin, alpha 5, is highly expressed in the secretory granules of Paneth cells of the ileum. [provided by RefSeq, Oct 2014]'