Human Deoxyguanosine kinase (DGUOK) activation kit by CRISPRa

CAT#: GA101191

DGUOK CRISPRa kit - CRISPR gene activation of human deoxyguanosine kinase

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: DGUOK
• Locus ID: 1716
• Kit Components:

  GA101191G1, Deoxyguanosine kinase gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101191G2, Deoxyguanosine kinase gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101191G3, Deoxyguanosine kinase gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001318859, NM_001318860, NM_001318861, NM_001318862, NM_001318863, NM_001929, NM_080915, NM_080916, NM_080917, NM_080918, NR_134893, NR_134894, NR_134895, NR_134896, NR_134897, NR_134898
• Synonyms: deoxyguanosine kinase; deoxyguanosine kinase, mitochondrial; dGK; OTTHUMP00000160251; OTTHUMP00000160252
• Summary: 'In mammalian cells, the phosphorylation of purine deoxyribonucleosides is mediated predominantly by two deoxyribonucleoside kinases, cytosolic deoxycytidine kinase and mitochondrial deoxyguanosine kinase. The protein encoded by this gene is responsible for phosphorylation of purine deoxyribonucleosides in the mitochondrial matrix. In addition, this protein phosphorylates several purine deoxyribonucleoside analogs used in the treatment of lymphoproliferative disorders, and this phosphorylation is critical for the effectiveness of the analogs. Alternative splice variants encoding different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2008]'