Human DKC1 activation kit by CRISPRa

CAT#: GA101205

DKC1 CRISPRa kit - CRISPR gene activation of human dyskerin pseudouridine synthase 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: DKC1
• Locus ID: 1736
• Kit Components:

  GA101205G1, DKC1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101205G2, DKC1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101205G3, DKC1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001142463, NM_001288747, NM_001363, NR_110021, NR_110022, NR_110023
• Synonyms: CBF5; DKC; DKCX; NAP57; NOLA4; XAP101
• Summary: 'This gene functions in two distinct complexes. It plays an active role in telomerase stabilization and maintenance, as well as recognition of snoRNAs containing H/ACA sequences which provides stability during biogenesis and assembly into H/ACA small nucleolar RNA ribonucleoproteins (snoRNPs). This gene is highly conserved and widely expressed, and may play additional roles in nucleo-cytoplasmic shuttling, DNA damage response, and cell adhesion. Mutations have been associated with X-linked dyskeratosis congenita. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]'