Human SARDH activation kit by CRISPRa

CAT#: GA101221

SARDH CRISPRa kit - CRISPR gene activation of human sarcosine dehydrogenase

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: SARDH
• Locus ID: 1757
• Kit Components:

  GA101221G1, SARDH gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101221G2, SARDH gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101221G3, SARDH gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001134707, NM_007101
• Synonyms: BPR-2; DMGDHL1; SAR; SARD; SDH
• Summary: 'This gene encodes an enzyme localized to the mitochondrial matrix which catalyzes the oxidative demethylation of sarcosine. This enzyme is distinct from another mitochondrial matrix enzyme, dimethylglycine dehydrogenase, which catalyzes a reaction resulting in the formation of sarcosine. Mutations in this gene are associated with sarcosinemia. Alternatively spliced transcript variants have been described. [provided by RefSeq, Oct 2008]'