Human Dynamin 1 (DNM1) activation kit by CRISPRa

CAT#: GA101223

DNM1 CRISPRa kit - CRISPR gene activation of human dynamin 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: DNM1
• Locus ID: 1759
• Kit Components:

  GA101223G1, Dynamin 1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101223G2, Dynamin 1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101223G3, Dynamin 1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001005336, NM_001288737, NM_001288738, NM_001288739, NM_004408
• Synonyms: DNM
• Summary: 'This gene encodes a member of the dynamin subfamily of GTP-binding proteins. The encoded protein possesses unique mechanochemical properties used to tubulate and sever membranes, and is involved in clathrin-mediated endocytosis and other vesicular trafficking processes. Actin and other cytoskeletal proteins act as binding partners for the encoded protein, which can also self-assemble leading to stimulation of GTPase activity. More than sixty highly conserved copies of the 3' region of this gene are found elsewhere in the genome, particularly on chromosomes Y and 15. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]'