Human DMRT1 activation kit by CRISPRa

CAT#: GA101225

DMRT1 CRISPRa kit - CRISPR gene activation of human doublesex and mab-3 related transcription factor 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: DMRT1
• Locus ID: 1761
• Kit Components:

  GA101225G1, DMRT1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101225G2, DMRT1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101225G3, DMRT1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_021951, NM_001363767
• Synonyms: CT154; DMT1
• Summary: 'This gene is found in a cluster with two other members of the gene family, having in common a zinc finger-like DNA-binding motif (DM domain). The DM domain is an ancient, conserved component of the vertebrate sex-determining pathway that is also a key regulator of male development in flies and nematodes. This gene exhibits a gonad-specific and sexually dimorphic expression pattern. Defective testicular development and XY feminization occur when this gene is hemizygous. [provided by RefSeq, Jul 2008]'