Human DNA2 activation kit by CRISPRa

CAT#: GA101227

DNA2 CRISPRa kit - CRISPR gene activation of human DNA replication helicase/nuclease 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: DNA2
• Locus ID: 1763
• Kit Components:

  GA101227G1, DNA2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA101227G2, DNA2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA101227G3, DNA2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001080449, NR_102264
• Synonyms: DNA2L; hDNA2
• Summary: 'This gene encodes a member of the DNA2/NAM7 helicase family. The encoded protein is a conserved helicase/nuclease involved in the maintenance of mitochondrial and nuclear DNA stability. Mutations in this gene are associated with autosomal dominant progressive external ophthalmoplegia-6 (PEOA6) and Seckel syndrome 8. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2014]'